Syn-Coll (Palmitoyl Tripeptide-5)

Key points

• Syn-Coll is Palmitoyl Tripeptide-5, a short peptide with a fatty group added to help it absorb.
• It is marketed to support collagen and reduce the look of wrinkles.
• On the skin, with no medicinal claims, it is regulated as a cosmetic ingredient in the UK.
• The evidence is modest, and cosmetic claims are best kept in proportion.

Quick facts

What it is

Cosmetic skincare peptide (Palmitoyl Tripeptide-5)

Marketed for

Collagen support and wrinkles

UK status

Legal as a cosmetic ingredient (no medicinal claims)

Evidence

Modest

How it works

This peptide is used in cosmetics with the aim of encouraging the skin's own collagen, which gives skin its firmness. The fatty group helps it pass into the skin. Most of the supporting evidence is from laboratory and manufacturer studies.

What the evidence shows

There are studies, often from manufacturers, suggesting modest improvements in firmness and the look of wrinkles. Independent, high quality trials are limited, so claims should be kept modest.

What it does not settle

• Independent high quality evidence is limited.
• Effects are usually modest and build slowly.
• Results depend on the product and how it is used.

Side effects

Common

• Usually well tolerated, though some people get mild irritation or redness. A patch test is sensible.

Report any suspected side effect through the MHRA Yellow Card scheme.

UK legal status and access

As a topical cosmetic ingredient with no medicinal claims, Syn-Coll is legal and widely sold in skincare. Any version sold with medicinal claims would fall under medicines rules.

Common questions