Palmitoyl Dipeptide-6

Key points

• Palmitoyl Dipeptide-6 is a short peptide with a fatty group added to help it absorb into the skin.
• It is marketed to firm the skin and soften the look of fine lines.
• On the skin, with no medicinal claims, it is regulated as a cosmetic ingredient in the UK.
• The evidence is modest, and cosmetic claims are best kept in proportion.

Quick facts

What it is

Cosmetic skincare peptide

Marketed for

Firmness and fine lines

UK status

Legal as a cosmetic ingredient (no medicinal claims)

Evidence

Modest

How it works

Short peptides like this are used in cosmetics to signal to skin cells, with the aim of supporting collagen and firmness. The fatty group helps it pass into the skin. Most of the supporting evidence is from laboratory and manufacturer studies.

What the evidence shows

There are studies, often from manufacturers, suggesting modest improvements in the look of skin. Independent, high quality trials are limited, so claims should be kept modest.

What it does not settle

• Independent high quality evidence is limited.
• Effects are usually modest and build slowly.
• Results depend on the product and how it is used.

Side effects

Common

• Usually well tolerated, though some people get mild irritation or redness. A patch test is sensible.

Report any suspected side effect through the MHRA Yellow Card scheme.

UK legal status and access

As a topical cosmetic ingredient with no medicinal claims, Palmitoyl Dipeptide-6 is legal and widely sold in skincare. Any version sold with medicinal claims would fall under medicines rules.

Common questions