GHRP-2

Key points

• GHRP-2 is a six amino acid peptide that works through the ghrelin receptor to trigger a pulse of growth hormone.
• In Japan a form is approved for a single use diagnostic test of growth hormone, called pralmorelin.
• It raises appetite, and cortisol and prolactin, though less than GHRP-6 relative to its growth hormone effect.
• It has no UK marketing authorisation, and growth hormone releasing peptides are prohibited in sport.

Quick facts

What it is

Growth hormone releasing peptide, 6 amino acids

Known for

More potent GH release; raises appetite

UK status

Not a licensed medicine; sold for research use

Human evidence

Diagnostic use; no benefit trials

In sport

On the WADA Prohibited List

How it works

GHRP-2 binds the ghrelin receptor on pituitary cells, producing a pulse of growth hormone that raises IGF-1. Because that receptor also drives hunger, appetite goes up. It adds to the effect of a GHRH analogue such as CJC-1295 or sermorelin, which is why the two types are often paired in practice.

What the evidence shows

Its most established use is the diagnostic test in Japan. Otherwise the human data is short term, in healthy volunteers or people with growth hormone deficiency. There are no large controlled trials for body composition or ageing, no settled dose, and no long term safety data.

What it does not settle

• There are no large trials for the uses it is marketed for.
• Long term effects on cortisol, prolactin and insulin sensitivity are not established.
• There is no settled human dose for ongoing use.

Side effects

Common

• Increased appetite, water retention, and injection site reactions.
• A temporary rise in cortisol and prolactin.

Less common but serious

• Sustained high growth hormone can reduce insulin sensitivity, so blood sugar is worth watching.
• Because there is no licensed product, the dose, purity and contents of material bought online cannot be verified.

Report any suspected side effect through the MHRA Yellow Card scheme.

UK legal status and access

GHRP-2 has no UK marketing authorisation, so it is not a licensed medicine and is not offered by registered clinics or pharmacies. It is sold online labelled for research use. Genuine growth hormone deficiency is diagnosed and treated with licensed medicines under specialist care.

Common questions